Current RCTs of Nutrition / Nutrients in ICU patients



GLUTAMINE
No Title Principal Investigator Country ID # Status
1 Adjuvant Nutrition for Critically Ill Trauma Patients John A Rathmacher, Ph.D. US NCT00067132 Completed
2 CRISIS Prevention Study (PICU) Jeri L Burr, MS, RN-BC, CCRC and Spencer M Hawkes, MS, CCRC US NCT00395161 Recruiting
3 Efficacy and Mechanisms of GLN Dipeptide in the SICU Thomas R. Ziegler, MD US NCT00248638 Recruiting
4 Enteral Glutamine in Critical Illness Michael DePietro, M.D US NCT00318331 Terminated
5 Enteral Glutamine Supplementation for the Patient With Major Torso Trauma Margaret M McQuiggan, MS, RD, CNSD US NCT00178581 Terminated
6 Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients Mary-Liz C Bilodeau, MS and Yong-Ming Yu, PhD, MD US NCT00217035 Recruiting
7 Glutamine Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Gordon S Sacks, PharmD., FCCP, BCNSP US NCT00204958 Recruiting
8 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Luc CYNOBER, PhD France NCT00560157 Completed
9 Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients. Mary-Liz C Bilodeau, MS and Yong-Ming Yu, PhD, MD US NCT00216970 Recruiting
10 Study of Glutamate and Glutamine Metabolism in Burn Patients Receiving Enteral or Parenteral Nutrition Mary-Liz C Bilodeau, MS and Yong-Ming Yu, PhD, MD US NCT00181753 Not yet recruiting
11 Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in BurnsMary-Liz C Bilodeau, MS and Yong-Ming Yu, PhD, MD US NCT00216996 Recruiting
12 The Effect of Antioxidants on the Immune Response and Wound Healing in Critically Ill PatientsPierre Singer, MD and Miriam Theilla, RN Israel NCT00487097 Not yet recruiting
13 Trial of Glutamine and Antioxidant Supplementation in Critically Ill PatientsDaren Heyland, MD and John Muscedere, MD Canada NCT00133978 Recruiting
14 REducing Deaths due to OXidative Stress: a randomised trial of glutamine and anti-oxidant supplementation in critically ill patients Dr Daren Keith Heyland Canada ISRCTN48486094 Ongoing
15 Enteral Glutamine in Neurologically-Injured Patients Gordon S Sacks, PharmD US NCT00204971 Recruiting
LIPIDS/FISH OILS
16 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) Renee D. Stapleton, MD, MSc US NCT00351533 Active, not recruiting
17 Effect of an omega-3 fatty acid enriched lipid emulsion on acute respiratory distress syndrome (ARDS) Dr Mercè Planas Spain ISRCTN63673813 Completed
18 Clinical Assessment of Fish Oil-Based Lipid Emulsion Infusions in Critical Patients With Severe SepsisBoon-Siang Khor, MD Taiwan NCT00634075 Recruiting
19 Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study)David A. Schoenfeld, PhD and Arthur Wheeler, MD US NCT00609180 Recruiting
20 Enteral Feeding Study of Formula Containing Fish Oil in Critical Care SettingRobert Martindale, MD, PhD US NCT00421941 Completed
21 ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients.Jaume Jané Pujol, Product & Study Manager and Carlos Requena, Group Marketing Manager Spain NCT00396461 Recruiting
22 Omegaven (w-3 Fish Oil) Supplemented Parenteral Nutrition in Subjects of SICU.Hong-Shiee Lai, MD, PhD Taiwan NCT00172198 Recruiting
23 Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver FailurePierre-François Laterre, MD and Yvan Fleury, MD Belgium NCT00522730 Recruiting
24 Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)Pierre-François Laterre, MD and Yvan Fleury, MD Belgium NCT00488917 Recruiting
25 Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in Healthy Volunteers and ICU Patients (TPN)Guillermo Umpierrez, MD and Dawn Smiley, MD US NCT00672854 Recruiting
26 The Effects of EPA, GLA and Antioxidants in the Treatment of SepsisCarla Silva, RN and Alessandro Pontes-Arruda, MD, PhD Brazil NCT00329680 Recruiting
ENTERAL NUTRITION
27 A Research Study to Test (2) Two Different Types of Feeding Tubes Used in the Intensive Care UnitPaul Marik, MD US NCT00245687 Completed
28 The ENTERIC Study: The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care StudyAndrew Davies Australia NCT00163813 Not yet recruiting
29 TEvaluation of Jejunal Placement of Enteral Feeding TubesUlrike Holzinger, MD Austria NCT00500851 Completed
30 Evaluation of Two Enteral Nutrition Strategies in Mechanically Ventilated PatientsBruno François, MD France NCT00199641 Completed
31 Efficacy of Nasojejunal Enteral Feeding in Critically Ill Patients.Megan Robertson Australia NCT00256048 Completed
32 Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis (CRYSTMAS)Michael Hug, PhD France NCT00464204 Recruiting
33 Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patientsMichaël P Casaer, MD and Greet Van den Berghe, MD Ph D Belgium NCT00512122 Recruiting
34 Timing of Target Enteral Feeding in the Mechanically Ventilated PatientTodd W Rice, MD, MSc US NCT00252616 Recruiting
35 Pancreatitis, very early compared with selective delayed start of enteral feeding (PYTHON) trial Prof HG Gooszen Netherlands ISRCTN18170985 Ongoing
36 The incidence of ventilator associated pneumonia (VAP) in critically ill patients: comparison of enteral (EN) vs parenteral (PN) nutrition support. Dr Mark Palazzo United Kingdom ISRCTN86283280 Completed
PARENTERAL NUTRITION
37 Impact of Supplemental Parenteral Nutrition (SPN) on Clinical Outcome Measured by the Infection Rate, Duration of Mechanical Ventilation, and Rehabilitation in ICU PatientsNot Reported Switzerland NCT00802503 Recruiting
38 Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients (EPaNIC)Michaël P Casaer, MD and Greet Van den Berghe, MD Ph D Belgium NCT00512122 Recruiting
39 The effects of early parenteral nutrition compared to standard care on 60 day landmark mortality in the critically ill patient: A level I randomised controlled trial. Dr. Gordon S. Doig Australia ACTRN12605000704695 Not yet recruiting
EARLY VS LATE
40 Randomised prospective multicenter trial on the effect of early enteral nutrition on gut barrier permeability in severe acute pancreatitis.Mr Hemant Kocher United Kingdom ISRCTN12838218 Completed
41 A randomised controlled comparison of early post-pyloric versus early gastric feeding to meet nutritional targets in ventilated intensive care patients.Hayden White Australia ACTRN12606000367549 Not yet recruiting
42 Impact of Early Parenteral Nutrition completing enteral nutrition In adult Critically ill patients.Prof Greet Van den Berghe Belgium ISRCTN76223876 Ongoing
GLYCEMIC CONTROL
43 The impact of hypocaloric diet with intensive insulin therapy on mortality and morbidity in adult critically ill patientsDr Yaseen Arabi Saudi Arabia ISRCTN96294863 Completed
44 The effect of exogenous glucagon-like peptide-1 (GLP-1) compared to placebo on glycaemia in critically ill patients during small intestinal feedingAdam Deane Australia ACTRN12609000093280 Recruitment Completed
45 A randomised controlled trial investigating the effect of strict glycaemic control on the incident of nosocomial infection in critically ill patients Dr Barbara Philips United Kingdom ISRCTN24412536 Completed
46 A multi-centre, open label randomised stratified controlled trial of the effects of blood glucose management on 90-day all-cause mortality in a heterogeneous population of intensive care unit (ICU) patientsProf Simon Finfer Australia ISRCTN04968275 Ongoing
PROBIOTICS
47 Probiotic Enteral Administration in Mechanically Ventilated PatientsSebastien Gibot, MD, PhD France NCT00122408 Recruiting
48 Lactobacillus GG in the Prophylaxis of Ventilator Associated PneumoniaLee Morrow, MD US NCT00613795 Suspended [currently analyzing data collected thus far]
49 The Effect of Prophylactic Probiotic Lactobacilli in Enteral Feeding on Nosocomial Pneumonia Rates in Critically Ill PatientsMegan Robertson and Deborah Barge Australia NCT00256087 Recruiting
50 Influence of symbiotics in the outcome of multiple organ dysfunction syndrome: a prospective, aleatorised, randomised controlled trial Dr Ismael López de Toro Martín-Consuegra Spain ISRCTN22361317 Ongoing
51 A study comparing a suspension of Lactobacillus plantarum 299 with chlorhexidine for oral care in intubated mechanically ventilated patients in intensive careDr Bengt Klarin Sweden ISRCTN00472141 Completed
52 Can Lactobacillus plantarum 299v in fermented oat meal gruel prevent overgrowth of Clostridium difficile in the Gastrointestinal (GI) tract in antibiotic treated critically ill patients?Dr Bengt Klarin Sweden ISRCTN85655545 Completed
OTHER
53 Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated PatientsKenneth Kudsk, MD US NCT00205309 Recruiting
54 Anabolic Steroids for Nutritional Rehabilitation of Critically Ill PatientsMichael D Sharpe, MD FRCPC Canada NCT00242463 Recruiting
55 Comparison of Two Strategies for Glycemic Control in Acute Ischemic StrokeJOSE R AZEVEDO, MD Brazil NCT00747279 Recruiting
56 Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care UnitJames M. O'Brien, MD US NCT00296088 Completed
57 Hemodynamics and Extravascular Lung Water in Acute Lung Injury (HEAL)Alex Nielsen and Charles Phillips, M.D. US NCT00624650 Recruiting
58 Hyperproteic Nutrition: Correlation of BUN to Nitrogen BalanceJohn K Stene, MD US NCT00480259 Not yet recruiting
59 ICU Nutrition Study BernStephan Jakob, MD, PHD and Zeno Stanga, MD Switzerland NCT00574431 Recruiting
60 Immunonutrition and Thoracoabdominal Aorta Aneurysm RepairErik Scholten, MD and Gert B Brunnekreef, MD Netherlands NCT00339053 Recruiting
61 N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed TomographyClaudio M Martin, MD, FRCPC, MSc Canada NCT00830193 Completed
62 Pharmacokinetic/ Pharmacodynamic Study of Epoetin Alfa (PROCRIT®) in Critically Ill Patients.Johnson & Johnson Pharmaceutical Research and Development, L.L.C. Clinical Trial US NCT00210756 Completed
63 Proline Metabolism in Severely Burned Patients: Effect of Modulated Parenteral FeedingRonald G Tompkins, MD, ScD US NCT00216983 Recruiting
64 N-acetylcysteine as a Preventive Measure for Contrast Induced Nephropathy in Intensive Care Patients with Renal Insufficiency Dr M J Schultz Netherlands ISRCTN43635237 Completed
65 A randomized controlled trial of immune-enhancing enteral feeding on immunologic and nutritional status in tube-fed patients Yoshiaki Takeuchi Japan UMIN000001326 Not yet recruiting